D-2- - N - acyl -L- glutamine

D-2- - N - acyl -L- glutamine - Names and Identifiers

Name	(S)-2-((R)-2-Chloropropanamido)-4-Carbamoylbutanoic Acid
Synonyms	Alanyl Glutamine Impurity 21 D-2- - N - acyl -L- glutamine ((R)-2-chloropropanoyl)-L-glutamine N2-[(2R)-2-chloro-1-oxopropyl]-L-Glutamine L-Glutamine, N2-[(2R)-2-chloro-1-oxopropyl]- (S)-2-((R)-2-Chloropropanamido)-4-Carbamoylbutanoic Acid (S)-2-((R)-2-CHLOROPROPANAMIDO)-4-CARBAMOYLBUTANOIC ACID (S)-5-AMino-2-((R)-2-chloropropanaMido)-5-oxopentanoic acid (2S)-5-amino-2-[[(2R)-2-chloropropanoyl]amino]-5-oxopentanoic acid
CAS	159141-33-0

D-2- - N - acyl -L- glutamine - Physico-chemical Properties

Molecular Formula	C8H13ClN2O4
Molar Mass	236.65
Density	1.359±0.06 g/cm3(Predicted)
Boling Point	600.5±55.0 °C(Predicted)
pKa	3.09±0.10(Predicted)
Storage Condition	2-8°C

D-2- - N - acyl -L- glutamine - Introduction

(S)-2-((R)-2-chroopanamido)-4-carbamoylbutylic Acid is an organic compound with the chemical formula C9H15ClN4O3. It is a white or almost white crystal, soluble in water and some organic solvents.

(S)-2-((R)-2-chroopanamido)-4-Carbamoylbutanoic Acid is commonly used as a reagent in biochemical research, mainly for the synthesis of peptides or protein chain N-terminal modification. It can react with amino groups of amino acids or peptide chains to introduce D-2-chloropropionyl groups into the N-terminus of the Target chain, thereby changing its properties or increasing its stability. In addition, it is also commonly used in the synthesis of drugs and other organic compounds.

The method of preparing (S)-2-((R)-2-Chloropropanamido)-4-Carbamoylbutanoic Acid is generally obtained by reacting chloroalkane with glutamine. First, the chlorinated alkane is added to the reaction solution, followed by the addition of the glutamine suspension, and the reaction is carried out under appropriate conditions for a certain period of time. Finally, the target product is obtained by the steps of filtration and crystallization.

When using (S)-2-((R)-2-chroopanamido)-4-Carbamoylbutanoic Acid, attention should be paid to its safety. It is a chemical that is irritating to the eyes and skin, and care should be taken to avoid direct contact. At the same time, it should be operated in a well-ventilated place to avoid inhaling its gas or dust. Wear appropriate personal protective equipment such as lab gloves, goggles and lab clothes during use. Avoid swallowing or long-term contact with the compound, such as accidentally swallowed or skin allergies and other discomfort, should be timely medical treatment.

Last Update：2024-04-09 21:11:58